Membranous Nephropathy Treatment: Advancements and Therapeutic Approaches
Membranous nephropathy is a kidney disorder characterized by the thickening of the glomerular basement membrane due to the accumulation of immune deposits. This condition often leads to nephrotic syndrome, which manifests through proteinuria, edema, hypoalbuminemia, and hyperlipidemia. While some patients may experience spontaneous remission, many require targeted treatment to manage symptoms, preserve kidney function, and prevent progression to chronic kidney disease.
The treatment of membranous nephropathy generally depends on disease severity, proteinuria levels, kidney function, and the presence of risk factors. For patients with mild symptoms or low-risk disease, supportive therapy is often the first line of management. This includes the use of angiotensin-converting enzyme (ACE) inhibitors or angiotensin II receptor blockers (ARBs) to reduce proteinuria and control blood pressure. Lifestyle modifications such as low-sodium diets, maintaining a healthy weight, and reducing cholesterol levels also play a crucial role in supportive care.
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